A comparative analysis of epidemiologic, clinical characteristics and long-term outcomes between pediatric and adult meningiomas clinical: A SEER database study
Meningioma represents the most common intracranial tumor among adults. However, it is rara in pediatric patients. We are aimed to compare the clinical characteristics and long-term outcome of pediatric meningiomas (PMs) and adult meningiomas (AMs).
We enrolled 211682 patients with PMs in the Surveillance, Epidemiology, and End Result (SEER) datasets from 2000 to 2020. Clinical characteristics, overall survival (OS) and disease specific survival (DSS) were compared between PMs and AMs. Univariate and multivariate Cox analysis were employed to evaluate the predictive values of clinical characteristics.
901 PM and 210781 AM patients were identified in the SEER datasets. The age-adjusted incidence rate of PMs ranged from 0.1 to 0.2 per 100,000 population. PMs accounted for 0.4-0.5% of all meningiomas from 2004 to 2020. The mean age of PM patients was 13.6±4.96 years. In comparison to AMs, PMs showed a notable male predominance (p<0.001), multiple system number (p<0.001), a predilection for spinal locations (p<0.001), malignant behaviors (p<0.001), and high WHO grade (p<0.001). Regarding treatment modalities, a significantly larger proportion of PM patients underwent surgery (p<0.001), postoperative radiotherapy (p<0.001), and systemic therapy (p<0.001). The mortality rate of PM patients was 6.55%, with a disease-specific mortality of 2.89%. Propensity score matching (PSM) was conducted between PM and AM cohorts. The survival analysis showed PMs had a significantly better OS (p<0.001) and DSS (p<0.001) when compared to the matched AM cohort. System number (p<0.001), tumor behavior (p=0.001), and systemic therapy (p=0.006) were determined as independent factors for the OS of PM patients. A nomogram with excellent accuracy was constructed based on the results of the multivariate Cox analysis.
PMs are extremely rare and show distinct clinical characteristics and outcomes when compared to AMs. They are characterized by male predominance, spinal location, multiple system diseases, malignant behavior and favorable OS.
We use cookies on our website. Cookies are small (text) files that are created and stored on your device (e.g., smartphone, notebook, tablet, PC). Some of these cookies are technically necessary to operate the website, other cookies are used to extend the functionality of the website or for marketing purposes. Apart from the technically necessary cookies, you are free to allow or not allow cookies when visiting our website.