Microscopy Conference 2023

Cryo-electron tomography of SARS-CoV-2 replication and assembly sites reconstituted in cells

LS 2: Cryo-tomography

Cryo-electron microscopy (cryoEM) and cryo-electron tomography (cryoET) provide us a high-resolution gateway to the molecular processes that underlie life. These techniques allow us to view biological molecules in their native state and at high resolution, to image and determine their dynamics and, moreover, their socio-molecular interactions. Still, improvements and developments in sample preparation, workflows that integrate different tools and co-localization strategies, along with new image processing approaches are needed to exploit the full potential of these methods. This session will discuss the latest technological advances and present tangible examples that demonstrate the strength of both cryoEM and cryoET.

Ralf Bartenschlager

Plenary speaker

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