During pregnancy progression and early childhood, in-utero and dietary factors can make important contributions towards health and development. In relation to studies of childhood diseases, serum proteomics of maturing infants can provide important insights, which, together with perinatal proteomes could reveal further biological perspectives.

In the present study, serum proteomics analyses of mother-infant dyads with HLA-conferred susceptibility to type 1 diabetes (n = 22), weaned to either an extensively hydrolyzed or regular cow"s milk formula, were made to determine differences between feeding groups and changes in infancy. Sera from the beginning of third trimester, the time of delivery, 3 months postpartum, cord blood and collected from the infants at 3, 6, 9 and 12 months were analyzed by LC-MS/MS.

Correlations were detected within the dyads on the basis of comparison of the ranked protein intensities. In addition, a range of perinatal and age-related changes were distinguished. A number of significant correlations with intestinal permeability were also noted.