We are excited to announce the 10th ECR Manuscript Competition at HUPO2024 to select the “Proteomics Highlight of the Year”. The manuscript competition is a unique opportunity for early career researchers to gain visibility in the proteomics community, as it serves as a platform to highlight the important contributions that postdoctoral fellows, young clinicians, and junior faculty members make to the proteomics field. Three finalists were selected to present their manuscripts published during the 2023 and 2024 calendar years in a dedicated plenary session at HUPO2024. An expert committee will evaluate the oral presentations to determine the “Proteomics Highlight of the Year”. The first-place winner and two runner-ups of this competition will be announced in the closing ceremony on Wednesday at HUPO2024 and receive a cash prize.