Tsubasa Takizawa (Tokyo/ JP), Seiya Ohtani (Tokyo/ JP), Narumi Watanabe (Tokyo/ JP), Naoki Miyazaki (Tokyo/ JP), Kei Ishizuchi (Tokyo/ JP), Koji Sekiguchi (Tokyo/ JP), Chisato Iba (Tokyo/ JP), Mamoru Shibata (Ichikawa/ JP), Ryo Takemura (Tokyo/ JP), Satoko Hori (Tokyo/ JP), Jin Nakahara (Tokyo/ JP)
Abstract text (incl. figure legends and references)
Question: Galcanezumab is the first anti-calcitonin gene-related peptide monoclonal antibody approved in Japan. How are the efficacy and safety of galcanezumab in patients with migraine in a real-world setting in Japan?
Methods: We retrospectively analyzed patients with migraine who received three doses of galcanezumab between August 2021 and February 2022 at the Keio University Hospital. We assessed changes in monthly migraine days (MMD), responder rate (RR), and migraine-associated and premonitory symptoms. We also investigated injection site reactions and adverse events.
Results: Fifty-two patients received three doses of galcanezumab during the study period. Compared to baseline, the MMDs decreased by 5.9 days (95% confidence interval, 4.2–7.7) at 3 months. The 50% RR was 61.5% at 3 months. A total of 64.9%, 50.0%, and 63.9% of patients showed improvement in the severity of photophobia, phonophobia, and nausea/vomiting, respectively. Premonitory symptoms persisted in 62.5% of patients. Moreover, injection site reaction was the most common adverse event (34.6%).
Conclusion: This study revealed the efficacy and safety of galcanezumab for migraineurs in Japan. Galcanezumab also improved migraine-associated symptoms. However, despite a reduction in headaches, premonitory symptoms persisted in >50% of the patients at 3 months, possibly due to a peripheral action of anti-calcitonin gene-related peptide monoclonal antibodies.