Evaluation of Serum Leptin Level in a Sample of Egyptian Patients with Migraine

Abstract text (incl. figure legends and references)

Background : Obesity is a risk factor for multiple neurological disorders including stroke , dementia and migraine . In addition , several cytokines and adipocytokines associated with migraine are modulated by body mass , which also act in the neurogenic inflammation in migraine . The aim of the study : was to throw light and asses leptin levels , one of the adipcytokines , in headache – free period of migraine patients and investigate its relation to vascular risk factors . Material and methods : Sixty – three patients with episodic migraine and 33 control subjects were enrolled in the study . All participants were subjected to full history taking and clinical examination , anthropometric measurements , Body mass index and fat mass values were calculated ,fasting blood glucose , lipid profiles and serum leptin assay by ELISA technique ,CT brain to exclude any brain lesions. Results : Leptin levels were found significantly lower in migraineurs than controls ( 21.16 ± 2.4 ng/ml , 35.48 ± 8.1 ng/ml ; p < 0.001 ) . Body mass index and fat mass were not differ between 2 groups . Conclusion : Migraine patients have lower leptin levels , which may be related to the pathogenesis of migraine . The importance of these findings on the prevalence , pathogenesis and treatment of migraine needs to be investigated in further detailed studies .

Table (1) : The Associations Between Leptin and Anthropometric Measurements in Migraine Patients

Leptin levels of migraineurs were correlated with age and WC

Graph 1

S LEPTIN

Relation between leptin level in migraine patient and duration of headache.

Graph 2

FBG

Relation between fasting blood glucose level in migraine patient and duration of headache