Hyperbilirubinemia as a risk factor of the trauma ICU

Abstract text (incl. references and figure legends)

Background: Hyperbilirubinemia is common in the intensive care unit (ICU). Hyperbilirubinemia has been considered as a risk factor of the ICU patient. Hyperbilirubinemia can have various causes. The hyperbilirubinemia has never been studied for the trauma ICU patient. The aim of this study is to elucidate the incidence and effects of the hyperbilirubinemia for the trauma ICU patient. Methods: Retrospective review of the Trauma ICU patients from 2017.01.01 to 2017.06.30. Initial bilirubin serum level, 48 hour bilirubin level, 7 day bilirubin level, highest bilirubin level, overall morbidity and mortality and other clinical variables were identified and evaluated. The patients who have highest bilirubin level >= 3.0 mg/dl were defined as hyperbilirubinemia group. Results: A total 78 patients were enrolled in this study. Hyperbilirubinemia above serum bilirubin >= 3.0 mg/dl were appeared in 26 patients. The mortality of the hyperbilirubinemia group was higher than the other group (71.4% vs 29.6%, p=0.03). The ICU stay of the hyperbilirubinemia group was longer than the other group (12.4 day vs 7.1 day, p=0.04). The hyperbilirubinemia group had more incidences of pneumonia, acute kidney injury, and sepsis than the other group (42.9% vs 57%, p=0.01/ 33.3% vs 66.7%, p=0.001/ 0% vs 100%, p< 0.001). Conclusion: The hyperbilirubinemia is a risk factor of the trauma ICU. If the hyperbilirubinemia is appeared, the cause of the hyperbilirubinemia should be evaluated and make an effort to correct hyperbilirubinemia for the each cause of the hyperbilirubinemia.

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