Hollie Jenkinson (Liverpool / GB), Weisang Luo (Liverpool / GB), Philippa Thorpe (Liverpool / GB)
Abstract text (incl. references and figure legends)
Introduction
Hip fracture patients are given medications at anaesthetic induction, which may include tranexamic acid (TXA) and dexamethasone. We aimed to investigate if either of these medications had an effect on the mortality of hip fracture patients. We also investigated if there was a difference in mortality rates between diabetic and non-diabetic patients, due to known effects of steroids on glucose homeostasis.
Material and Methods
Patients were selected from the local National Hip Fracture Database from February 2020 to August 2020. Data collected included injury type, management type, patient survival, diabetic status and anaesthetic medicines administered. Survival comparison significance was assessed by Fisher"s exact test.
Results
393 cases were identified, with 9 cases excluded due to incomplete records. 384 cases were included for analysis. There was a statistically significant worse mortality between patients who were given dexamethasone alone (68.1%) or TXA alone (78.4%) compared to those who were given both TXA and dexamethasone (86.1%). There was no significant statistical difference between the diabetic and non-diabetic patients receiving any combination of these drugs.
Conclusions
TXA and dexamethasone in combination seem to have a positive effect compared to with dexamethasone alone in this vulnerable patient cohort. Our data suggests that the pathological process in diabetes has no effect on the outcomes of using either drug, alone or together.
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