Abstract text (incl. references and figure legends)
Surgical-site infections (SSIs) can lead to greater postoperative morbidity, mortality, and health care costs. Despite current prophylactic measures, rates of SSIs after osteosynthesis have been reported in up to 67% in high-energy fractures. The local application of vancomycin in its powder form ensures adequate surgical-site concentrations while minimizing adverse effects caused by undetectable systemic distribution. The aim of this article is to review the current literature for studies on the intra-wound application of vancomycin powder in fractures treated with osteosynthesis and to analyze its effectiveness in the prevention of postoperative SSI.
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