Ergebnisse des Verhältnisses von löslichem Transferrinrezeptor/Ferritin (sTfR/SF) und der Hämoglobinkonzentration als prädiktives Maß zur Erkennung von Eisenmangel bei häufigen Blutspenden in Nigeria
Dorathy Okpokam (Calabar / NG), Ehijie Iyamah (Benin / NG), Nkeiruka Ogidi (Lagos / NG), Chukwuka Opara (Calabar / NG), Eme Osim (Calabar / NG), Esien Usanga (Calabar / NG), Anthony Emeribe (Calabar / NG)
Maintaining donor health is of paramount than ensuring a safe, ceaseless blood supply, and blood bays should scout for screening programs for donors to improve their health, recruitment, and withholding.
One hundred and eighty-four (184) subjects comprising five groups were recruited into this study, that is, 35 (19.0%) control group, 32 (17.4%) of first, 35 (19.0%) of second, 41 (22.3%) of third and 41 (22.3%) of fourth time blood donors. The donors were within the range of 18 – 49 years of age. Whole blood and serum samples (sera) were used and parameters namely; haemoglobin concentration (Hb) was determined using colorimetric method, serum ferritin level (SF) and serum transferrin receptor level (STfR) were determined using enzyme immunosorbent assay (ELISA), while sTfR was determined by dividing sTfR by SF and finding log of result.
Age of donors display that bulk of their ranged 18 -25 in age (45.7%) and 26 – 35 years (47.3%) while ≥ 36 years (7.1%) were very few. 62.5% of 184 blood donors were remunerated while 37.5% were not at the time of donation. Moreover, 26.6% of blood donors donated elsewhere other than the facility while 73.4% donated in the facility. The mean values of Hb and SF decreased significantly (p < 0.001). It was from (152g/L, 142g/L, 125g/L, 115g/L and 103g/L) for the control group to fourth time male donors for Hb, and (101.7, 104.8, 50.1, 33.5 and 21.3 ng/ml) for SF as the number of donation increased within a year. Meanwhile, mean value of sTfR and sTfR/SF ratio from control group to fourth time male blood donors were raised as donation increased significantly (p < 0.01) (2.7, 3.7, 6.6, 8.3 and 10.9 µg/ml) and (1.41, 2.09, 4.76, 8.04 and 14.2 µg/ng) respectively. Male blood donors with iron-deficient as defined by Hb (<125g/L) was 43.5%, SF (<15ng/ml) was 35.3%, sTfR (>3.5µg/ml) was 57.6% and sTfR/SF ratio (>2.5µg/ng) was 56.5% in all 184 male blood donors.
Of all the indices used to diagnose iron deficiency, sTfR and sTfR/SF ratio produced the highest percentages of 56.5% and 57.6% respectively of the donors thus, making these indices the most sensitive to diagnose iron deficiency. Blood banks should determine the Hb levels, SF, sTfR and its ratio of blood donors at the time of donor screening to give adequately, the total number of donors having iron deficiency. Also, voluntary non-remuneration should be encouraged.
The authors declared no conflicts og Interest