8th German Pharm-Tox Summit

Development of FRET-based receptor conformation sensors for the opioid receptor family and analysis of opioid agonist properties

G-protein coupled receptors

<B>Posters will be presented during the time period mentioned above. This will give all participants and the poster jury the opportunity to interact with the presenting authors. Please be available to answer questions at your poster during the poster session.  

Session 1

Poster

Signal transduction and second messengers		 	

Two lysines in the N-terminus of arrestin control binding and release of the arrestin C-terminus upon binding to GPCRs

Oral presentation

Role of Ubiquitination for co-internalization of arrestin3 with G protein coupled receptors

<B>Posters will be presented during the time period mentioned above. This will give all participants and the poster jury the opportunity to interact with the presenting authors. Please be available to answer questions at your poster during the poster session. </B>


Session 2

FRET-based neurotensin 1 receptor conformation sensor to study on- and off-kinetics in intact cells and under cell-free conditions

Agonist affinity of prostanoid receptor sensors decreases in non-intact cells

Immunopharmacology / inflammation / anti-infectives	

Human DP2 receptor based FRET conformation sensor gives new insights into pharmacology and reveals arachidonic acid to be a partial agonist DP2 receptor

Prof. Dr.

Moritz Bünemann

Further involvements