Überleben von Patienten mit neu diagnostiziertem Glioblastom: Outcome bei infra- vs. supratentorieller Lokalisation.

Due to the rare incidence of cerebellar glioblastoma, clinical outcome data are scarce. The authors performed propensity score matching between patients with infra- and supratentorial glioblastoma and analyzed their institutional database with regard to potential prognostic differences between cerebellar and supratentorial glioblastoma patients.

Between 2009 and 2020, 8 patients underwent surgery for cerebellar glioblastoma at the author's institution. In order to produce a covariate balance optimization for commonly known prognostic predictors (age, preoperative Karnofsky Performance Scale (KPS), extend of resection (EOR), MGMT-promoter methylation status), a propensity score matching at a ratio of 1:4 between a cohort of patients with infratentorial glioblastoma and a cohort of 205 patients with supratentorial glioblastoma was performed using R. A systematic review of the contemporary literature was performed in order to compile survival data of cerebellar glioblastoma patients.

Cerebellar glioblastoma patients exhibited a median overall survival (OS) rate of 18 months (95% confidence interval (CI) 11-25). Compared with this, median OS for the group of 32 individually matched patients with supratentorial glioblastoma was 23 months (95% CI 23 (0-62)) (p = 0.63). A systematic review revealed OS rates for glioblastoma patients between 6 up to 21 months.

The present study suggests that theprognostic value of infra- and supratentorial glioblastoma location following at least STR does not significantly differ. The establishment of large-scale, multicenter databases is needed in order to be capable of adequately addressing this underrepresented subpopulation of glioblastoma patients.