A new antibiotic: Evaluation of a Photoactivatable Ciprofloxacin and the role of Bile Acids to diminish Biofilms on Bile Duct Catheters

We would like to present the effectiveness of a newly developed photoactivatable ciprofloxacin on pathogenic bacteria and biofilms derived infections associated with biliary catheters. The research addresses the challenge of elusive bile microbiomes linked to hepatobiliary diseases, particularly those resulting from biofilms on internal-external biliary drainage catheters WE could demonstrate that the photo-activated antibiotic effectively prevents biofilm formation and reduces bacterial viability without harming eukaryotic cells. Additionally, the combined impact of bile acids in combination with antibiotics was investigated. A combinational treatment involving antibiotics and bile acids, such as ursodesoxycholic acid (UDCA), shows promise in reducing bacterial survival within biofilms. The findings provide evidence for mode of action of the treatment of UDCA in biliary infections, like cholangitis.