• Poster
  • RF 17

Traumatic fracture treatment: Calcium phosphate bone substitute case-control study in humerus, radius, tibia fractures – assessing efficacy and recovery outcomes

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Topics

  • Clinical applications and translation
  • Implant associated

Abstract

Abstract text (incl. figure legends and references)

This study investigates the safety, resorption, healing process, and complications of synthetic bioactive bone substitute materials, specifically calcium phosphate-based bone substitutes (CP), in traumatically induced bone fractures. We hypothesize that CP could improve bone healing.

In this retrospective case-control study, over 290 patients who received surgical treatment for acute fractures were examined. CP augmentation was compared with empty defect treatment (ED) between 2011 and 2018. A new scoring system for fracture healing was used in up to six radiological follow-up examinations, and demographic data, concomitant diseases, and complications were analyzed.

Data analysis showed significantly fewer postoperative complications in the CP group compared to the ED group (p<0.001). Risks of pseudarthrosis (p<0.001), arthrosis (p=0.01), and neurological diseases (p<0.001) were decreased in the CP group. Intermediate follow-up examinations indicated enhanced fracture edge, gap, and articular surface (p<0.05). Osteosynthesis and general bone density were similar (p>0.05).

Subgroup analysis of patients aged over 64 years revealed fewer complications in the CP group (p=0.025). Geriatric patients benefited from CP materials with reduced pseudarthrosis (p=0.059) and improved fracture gap, edge, and articular surface in intermediate follow-ups (p<0.05).

In conclusion, calcium phosphate-based bone substitutes demonstrate safety in clinical applications, improved early osseous healing, and fewer severe complications. In vivo advantages were evident for CP bone graft substitutes.