Abstract text (incl. figure legends and references)
Introduction
Medical device-associated infections account for a large proportion of hospital-acquired infections. A variety of opportunistic pathogens can cause implant infections, depending on the type of the implant and on the anatomical site of implantation. To combat this, Graphene-based antimicrobial biomaterials have gained significant attention in recent years due to their diverse antimicrobial action and their biocompatibility.
Objectives
In this study, we discuss ongoing research about titanium functionalized with graphene and their interactions in microenvironments. The aim is to test the antimicrobial mechanisms of graphene-based materials and also it"s unique osteoblast growth promoting properties.
Materials & methods
Osteoblast cell line is tested in the presence of the GMs coated material for the cell adhesion and differentiation. Simultaneously, the material is tested for microbial adhesion in presence of two gram positive bacteria Staphylococcus aureus and Staphylococcus epidermidis.
Results
We expect to see osteoblast growth in presence of GMs. Additionally, we will present results from in vitro studies demonstrating the effectiveness of graphene-based novel materials in inhibiting bacterial growth and biofilm formation.
Conclusion
This research has the potential to pave the way for the development of novel hybrid materials for bone implants.