Association Between Migraine and Transient Global Amnesia: An Inpatient Sample Analysis

Abstract text (incl. figure legends and references)
Introduction: Transient global amnesia (TGA) constitutes an enigmatic amnestic syndrome characterized by temporary memory dysfunction of abrupt onset and total resolution within 24 h from emergence. Among the most prevailing theories implicates migraine and the neurophysiologic substrate of aura, which is caused by the release of massive glutamate and a subsequent wave of short-lasting cortical depolarization (CSD). Given this relationship between migraines and transient hippocampal dysfunction, it is feasible to consider the possibility of an etiological relationship between migraines and the transient memory problems in TGA individuals. The main focus of the study was to investigate the comorbidity of migraine among the TGA study population to analyze a potential association with TGA. Methods: Data extraction war performed between January 2007 and March 2021. Descriptive statistics were displayed as mean ± standard deviation for continuous data and frequencies with percentages for categorical variables. For group comparisons we used Chi-Quadrat-Test, Cramer’s V was performed to measure the relative strength of an association. The Mann–Whitney U test was used as analog nonparametric test. Results: From the study period of 14 years and 3 months 641 persons (62,1% women;37,9% men) with TGA were analyzed and evaluated. Mean age at the time TGA was diagnosed was 66,1 years of age (SD=10.02). Overall, 5,9% of the TGA persons preported a history of migraine. Furthermore, women with a history of migraine were 3,75 times more likely to suffer from TGA than men (p