Abstract text (incl. figure legends and references)
Background and aims:
(RCVS)characterized by the acute intense headache, focal and/or universal cerebral
symptoms, epileptic paroxysms,accompanied by reversible
segmental multifocal cerebral vasospasm, which disappears in three months.Aim of our study was to identify gene polymorphisms predisposing
to hereditarv thrombophilia in REVS patients
Methods: 24 patients (age 38+11 years) with RCVS were examined: 19 women (79.1%) aged 38.0+11.4 years,5 men
(20.8%) aged 38.2+11.3 years. There didn't find significant gender difference in age. Investigation included routine
clinica and neurological examination,neurolayme research methods (brain MRI on 1.5T or 3T, MR arterio-graphy) and molecular genetic study of polymorphisms predisposing to thrombophilia: G20210A of prothrombin
gene,C677T methylenetetrahydrofolate reductase gene, 675 4G/5G gene of endothelial plasminogen activator inhibitor (PA1-1, SERPINE1), 455 G/A gene of the beta-polypeptide chain of fioninogen
Results: Polymorphism G20210A in the prothrombin gene was not detected in the examined patients. Heterozygous
carriage in the methylenetetrahydrofolate reductase gene was observed in 10 patients - in nine women and one man
(43.5%), homozygous-in two women (8.3%). Polymorphism of the endothelial plasminogen activator inhibitor gene was
detected in 16 patients (12 women and four men) in the heterozygous state (66.7%) and in three - in the homozygous
state (12.5%). Polymorphism 455 G/A was detected in heterozygous state in six patients (25%): five women and
one man and in homozygous state in four patients 16.7%- two women and two men
Conclusion: The role of the revealed changes in the development of the complicated course of CVS requires
further study.