Abstract text (incl. figure legends and references)

Purpose: To study the features of cognitive impairment in patients with migraine and migraine comorbid epilepsy.

Materials and methods: 47 patients with migraine comorbid epilepsy were examined. Of these, there were 16 men (34%), women - 31 (66%), the average age of which was 27.4±2.2 years. For the control group, 128 patients with migraine were examined, of which 82 (64%) were women, 46 (36%) were men, the average age of which was 27.5±2.1. Cognitive function was studied using the MMSE test, MSCT/MRI of the brain.

Results: Migraine with aura was diagnosed in 20 (42.6%) patients, migraine without aura 27 (57.4%) caused an epileptic attack. In 5 (10.6%) cases, one seizure was detected, in the remaining 42 (89.4%) cases, two or more episodes of seizures were detected. In the control group, 26 (20.3%) patients were diagnosed with migraine with aura, 95 (74.2%) patients with migraine without aura. Studying cognitive function, it was found that 85.1% (n=40) of patients with migraine comorbid epilepsy had moderate and mild cognitive impairment. In the control group, only 27.3% (n=35) of cases had moderate cognitive impairment. Neuroimaging revealed ischemic changes in the cerebral cortex, periventricular and subcortical white matter in 87.2% (n=41) of cases in the main group and in 38.3% (n=49) of patients in the control group. MMSE data had a direct correlation with MRI/MSCT data with P<0.001 changes.

Conclusions: Accession of an epileptic seizure in migraine is combined with a decrease in cognitive function and is associated with vascular complications of the brain. Cognitive impairment in migraine comorbid epilepsy requires correction of this condition.