Abstract text (incl. figure legends and references)

Question

Real-world data are limited for people who use a calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) for preventive treatment of migraine. We assessed respondent characteristics and patient-reported improvement among current CGRP mAb users in the OVERCOME (EU) study.

Methods

Data were obtained from a cross-sectional web-based survey (2020-2021). Adult respondents fulfilled International Classification of Headache Disorders (ICHD‐3) criteria for migraine or had a self-reported physician diagnosis. This analysis assessed clinical and demographic characteristics in those who had ever used erenumab, fremanezumab or galcanezumab. Moreover, current users of a single mAb completed the Patient Global Impression of Improvement (PGI-I) to assess improvement in current migraine condition. Analyses were descriptive.

Results

Of 20,756 respondents, 2167 (10.4%) reported ever using a CGRP mAb. Among these, the mean (standard deviation [SD]) age was 32.9 (10.4) years, 38.8% were female, and the mean (SD) headache days/month (HD/m) was 3.4 (4.4). More than 1/3 of respondents (34.1%) had severe migraine-related disability (MIDAS score >=21), 30.8% moderate (11-20), 21.8% mild (6-10), and 13.3% little to none (<=5). The vast majority had used at least 1 additional traditional preventive medication. A total of 940 respondents (43.4%) had used a single CGRP mAb within the past 3 months. Among them, most respondents (77.3%) reported their migraine condition as "better" based on the PGI-I since starting the CGRP mAb. This was consistent across HD/m categories.

Conclusions

Most respondents taking a CGRP mAb for the preventive treatment of migraine reported their migraine as better since starting the medication.