Abstract text (incl. figure legends and references)

Purpose: Choice of the most effective anticonvulsant in patients with migraine comorbid epilepsy (MCE).

Materials and methods: In the period from 2018 to 2021, 18 patients with a diagnosis of migraine comorbid epilepsy applied to the department of the consultative polyclinic of the Tashkent Medical Academy. The patients underwent examination, ID-Migraine test, VAS, MIDAS, IPSS-QoL and EEG (again in a month), MRI of the brain.

Results: The diagnosis was made according to the ID-Migraine criteria and the International Headache Classification 3-Revision (ICHD-3). Women 12 (66.7%), men 6 (33.3%), mean age 27.4±0.4. Neurologic examination without features. The mean VAS was 6.9, which indicates a pronounced intensity of headaches. According to the MIDAS scale, the average value is 15.6 - in the main number of patients, headache makes everyday activity difficult. The quality of life was reduced according to the IPSS-QoL test - global index = 39.9. In 14 (77.7%) cases, convulsions had a primary generalized character, in 4 (22.3%) patients, partial convulsions with transitions to generalization were determined. On the EEG foci were determined. Patients were divided into equal 2 groups, while the difference between the VAS, MIDAS and IPSS-QoL scores of the 2 groups was not statistically significant. In order to prevent migraine and relieve seizures, the first group of patients was given Carbamazepine 400-600 mg/day, the patients of the second group received Valproic acid 1000 mg/day. Upon re-examination, in all patients, the frequency and intensity of headaches decreased, daily activity and quality of life improved with a predominance in the first group. The EEG also showed positive dynamics with prevalence in the first group.

Conclusions:Patients with MCE Carbamazepine gave a better result compared to valproic acid.This conclusion is not a criterion for choosing the drug and requires further research.