Manjit Matharu (London/ GB), Zaza Katsarava (Unna/ DE), Dawn C. Buse (Bronx, NY/ US), Katherine Sommer (Irvine, CA/ US), Michael Reed (Chapel Hill, NC/ US), Kristina Fanning (Wilmington, NC/ US), Richard B. Lipton (Bronx, NY/ US)
Abstract text (incl. figure legends and references)
Objective: To characterize the frequency and burden of neck pain with headache (NPWH) among individuals with and without migraine.
Methods: CaMEO-I was a prospective web-based survey conducted during 2021-2022 in Canada, France, Germany, Japan, United Kingdom, and United States. Respondents with ≥1 headache in the past year were divided into two groups: those meeting ICHD-3 migraine criteria based on a validated questionnaire and those with non-migraine headache (NMH). In both groups, NPWH was defined as reporting NPWH more than rarely. Within the migraine group, monthly headache days (MHDs), migraine-related disability (MIDAS), allodynia (ASC-12), depression and anxiety symptoms (PHQ-4), work productivity and activity impairment (WPAI), and acute treatment optimization (mTOQ) were evaluated in those with and without NPWH using validated measures.
Results: NPWH was reported by a higher proportion of respondents with migraine (63.4% [UK]‒75.0% [Germany]) versus NMH (31.4% [UK]‒44.8% [Germany]; Figure 1A). Migraine respondents with NPWH were more likely to have higher MHDs than those without NPWH in all countries. Among migraine respondents, moderate to severe MIDAS scores (MIDAS ≥11) were reported more frequently among those with NPWH (35.6% [Japan]‒55.3% [Germany]) than those without NPWH (19.8% [Japan]‒42.3% [Germany]; Figure 1B). Depression and anxiety symptoms, and allodynia were greater in respondents with NPWH versus those without (Table). Impairment in daily activities and while at work, work time missed, and overall work impairment were higher among those with versus without NPWH. "Poor" to "very poor" treatment optimization was reported more frequently in those with versus without NPWH.
Conclusions: NPWH occurred more frequently among respondents with migraine versus those with NMH. Among those with migraine, NPWH was associated with more frequent headaches and greater disability compared to those without NPWH. International differences will be discussed.