Abstract text (incl. figure legends and references)

OBJECTIVE: In DELIVER, eptinezumab reduced migraine frequency in patients with migraine and prior preventive treatment failures. This analysis evaluates patient-reported outcomes (PROs) over 24 weeks.

METHODS: DELIVER (NCT04418765) randomized and treated patients with intravenous eptinezumab 100mg, 300mg, or placebo every 12 weeks. The assessed PROs include EuroQol 5-Dimensions 5-Levels visual analogue scale (EQ-5D-5L VAS; higher scores better); 6-item Headache Impact Test (HIT-6; lower scores better), Patient Global Impression of Change (PGIC; lower scores better), most bothersome symptom (MBS; lower scores better), and Migraine-Specific Quality of Life Questionnaire (MSQ, v2.1; higher scores better).

RESULTS: Patients received eptinezumab 100mg (n=299), 300mg (n=294), or placebo (n=298). Mean changes from baseline to Week 12 (Wk12) in EQ-5D-5L VAS scores were 2.0 (100mg, P=0.0007) and 4.4 (300mg, P<0.0001) versus -3.1 (placebo), and were maintained or improved to Wk24 (2.0, 5.2, -2.8, respectively). Mean baseline HIT-6 total scores were ~66.4, with mean changes at Wk12 of -6.9 (100mg, P<0.0001) and -8.5 (300mg, P<0.0001) versus -3.1 (placebo) that were improved through Wk24 (-8.9, -9.9, -3.9). PGIC, MBS, and MSQ scores showed greater improvement for eptinezumab than placebo.

CONCLUSION: In adults with migraine and prior preventive treatment failures, eptinezumab robustly improved health-related quality of life and reduced migraine-related burden over 24 weeks versus placebo.