Abstract text (incl. figure legends and references)

[Objectives] To investigate the differences in pathophysiology between cluster headache (CH) and episodic migraine (EM), we studied static and dynamic resting-state functional connectivity (RSFC) between patients with CH and EM. [Methods] Nineteen patients with CH and 19 sex- and age-matched episodic migraineurs were selected for the study. All patients fulfilled the International Headache Society criteria 3 CH or EM. High-resolution structural magnetic resonance imaging (MRI) and resting-state functional MRI (RS-fMRI) were performed in both groups. [Results] Region of interest (ROI)-to-ROI analyses in static RS-fMRI revealed that patients with CH showed 13 higher connectivity pairs mainly between the right parahippocampal gyrus and other brain lesions and 2 lower connectivity pairs than patients with EM (Fig. 1). ROI-to-ROI analyses in dynamic RS-fMRI showed that t patients with CH showed 8 higher connectivity pairs than patients with EM (Fig. 2). All 8 pairs in dynamic RS-fMRI were different from 15 pairs in static RS-fMRI. [Conclusions] Our study showed some differences in RSFC between CH patients and episodic migraineurs. Our data also revealed that patients with CH had some higher connectivity than those with EM.