Maria Reigota Miranda (Aveiro / PT), Maria A. Costa (Aveiro / PT), Daniela Lira (Aveiro / PT), Ana C. Moreira (Aveiro / PT), Sofia Dias da Silva (Aveiro / PT), Alice Pimentel (Aveiro / PT), Marta Lopes Serra (Aveiro / PT), Vitor Francisco (Aveiro / PT), Margarida Martins (Aveiro / PT), Jorge Sousa (Aveiro / PT), Joana Noronha (Aveiro / PT)
Abstract text (incl. references and figure legends)
Case history: Neuroendocrine tumor (NET) of the appendix is the most common type of appendiceal cancer and is rare in the paediatric population. Appendiceal NET is detected in 0.1%-2.3% in all appendectomy specimens. The clinical manifestations of this cancer are not specific and could be very similar to those of acute appendicitis. Clinical findings:In th case report, a 14-year-old boy presented in our clinic with acute right lower quadrant abdominal pain and an ultrasound suggesting acute appendicitis complicated with an abscess. Investigation/Results: It was performed an emergency laparoscopic appendectomy. Diagnosis: The child was diagnosed with a NET of the appendix, by histopathological and immunohistochemistry examination of the specimen.Therapy and Progressions: After studying the tumor characteristics and the possibility of spread disease, it was performed a subsequent right hemicolectomy. Comments: The prognosis of the appendiceal NET is excellent, with more than 90% survival probability at 10 years and an overall risk of metastases of <10%.
References:
WHO Classification of Tumors Editorial Board. Digestive system WHO Classification of Tumors. 5th ed. Lyon: IARC press 2019. Rault-Petit B, Do Cao C, Guyétant S, et al. Current management and predictive factors of lymph node metastasis of appendix neuroendocrine tumors:a national study from the French Group of Endocrine Tumors. Ann Surg 2019;270:165-71.
Volante M, Grillo F, Massa F, et al. Neuroendocrine neoplasms of the appendix, colon and rectum. Pathologica 2021 Feb; 113:19-27. https://doi.org/10.1097/SLA.0000000000002736
Moris D, Tsilimigras D, Vagios S, et al. Neuroendocrine neoplasms of the appendix: a review of the literature. Anticancer Research 2018; 38: 601-612. doi: 10.32074/1591-951X-230
Morais C, Silva E, Brandão P, et al. Neuroendocrine tumor of the appendix – a case report and review of the literature. Journal of Surgical Case Reports 2019; 3:1-4. doi: 10.1093/jscr/rjz086
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