Dr. Behnaz Bayat (Gießen/ DE), Jonas Lowack (Gießen/ DE), Dr. Marie Audrain (Nantes/ FR), Laure Croisille (Créteil/ FR), Dr. Brian Curtis (Milwaukee, WI/ US), Rebecca Dangerfield (St. Paul, MN/ US), Behnaz Esmaeili (Teheran/ IR), Claudia Grabowski (Dessau/ DE), Margaret Keller (St. Paul, MN/ US), Hyungsuk Kim (Seoul/ DE), Dr. Hartmut Kroll (Dessau/ DE), Marjeta Macek Kvanka (Ljubljana/ SI), Janette Kwok (Hong Kong Sar/ HK), Elyse Moritz (Sao Paolo/ BR), Oytip Nathalang (Bangkok/ TH), Derrick Nelson (Johannesburg/ ZA), Kaspar René Nielsen (Aalborg/ DK), Gail Pahn (Brisbane/ AU), Anthony Poles (Bristol/ GB), Leendert Porcelijn (Amsterdam/ NL), Prof. Dr. Ulrich Sachs (Gießen/ DE), Marlies Schönbacher (Wien/ AT), Günther F. Körmöczi (Wien/ AT), Pawinee Kupatawintu (Bangkok/ TH), Daisuke Takahashi (Tokyo/ JP), Malgorzata Uhrynowska (Warsaw/ PL), Yoke-Lin Fung (Queensland/ AU)
Background
Human neutrophil antigens (HNA) are categorized into five subgroups (HNA-1 to -5). Given the importance of neutrophils in immunity, we sought to create awareness of the role of HNA diagnostic services in managing immune neutropenia and TRALI. To provide health communities all around the world with access to these services we conducted a survey to create a directory of these HNA diagnostic services.
Methods
An Excel table-based survey was created to capture information on the laboratory"s location and was emailed to 55 individuals with known or possible HNA investigation activity. The collected data were then summarized and analyzed.
Results
Of contacted laboratories, the surveys were returned from 23 (38.2%) labs; 17 have already established HNA diagnostic (Elabs; of them 12 were regular participant of International Granulocyte Immunobiology Workshop (ISBT-IGIW)), four labs were in the process of establishing their HNA investigation (LiD) and the remaining two responder labs, did not conduct HNA investigations. In Elabs, investigation for autoimmune neutropenia (infancies and adults) was the most frequently requested, and antibodies against HNA-1a and HNA-1b the most commonly detected.
Conclusion
The directory of survey respondents provides a resource for health professionals wanting to access HNA diagnostic services. The present study offers a comprehensive picture of HNA diagnostics (typing and serology), identifying weak points and areas for improvement for the first time. Identifying more laboratories involved in HNA diagnostics with limited access to international societies in the field will globally improve HNA diagnostics.
Offenlegung Interessenkonflikt:
NA