Einsatz des Multi-Target-Ansatzes bei der Tiefenhirnstimulation: Risiken und Komplikationen4o

The objective of this study is to evaluate the clinical outcomes and safety of multitarget stimulation (MTS) in patients with complex or atypical movement disorders (MD), pain syndromes, epilepsy, and psychiatric conditions. Specifically, this study assesses the potential benefits of MTS compared to single-target deep brain stimulation (DBS). Here, we focus on associated risks and complications.

We reviewed a cohort of 123 patients with various conditions, including Parkinson's disease, pain syndromes, dystonia, tremor, and Tourette syndrome, who underwent MTS with separate electrodes targeting different brain structures. Patients were selected based on the presence of multiple symptoms thought to be not adequately controlled by single target DBS. Clinical outcomes, complications, and adverse effects comparable were analyzed, and the results were compared to patients with single target DBS.

Among the analyzed patients, complications related to DBS included one case of intracranial hemorrhage (0.8%), 11 instances of wound healing disorders (8.9%), and 11 cases requiring electrode reimplantation (8.9%). These rates were slightly higher, but still comparable to patients who had single target DBS.

Multitarget stimulation (MTS) is a safe and effective approach for treating complex and

atypical disorders, with on acceptable rate of specific complications. Careful patient selection is crucial for minimizing risks and complications. Further research is warranted to establish standardized criteria for the use of MTS and optimal target selection.