7th joint conference "Joint Microbiology & Infection Conference 2024" of the DGHM and VAAM

Abstract: The last few decades has seen a tremendous increase in our understanding of the mechanisms underlying the development of protective anti-microbial immunity. Key among these discoveries is the identification of pattern recognition receptors (or PRRs) expressed by immune cells, which recognise conserved microbial components. Recognition of these structures by PRRs, such as members of the C-type lectin receptor (CLR) family, triggers intracellular signalling cascades that initiate a variety of cellular and inflammatory responses, and induce the development of pathogen-specific adaptive immunity. We now understand that innate recognition by CLRs is essential for the development of protective antimicrobial immunity, but that they also play a key role in other aspects of immunity. In this presentation, I will present an up to date overview of the role of these receptors in immunity, with a particular focus on anti-fungal immunity, and highlight some aspects of ongoing work from my laboratory.

C-type lectins – key regulators of anti-fungal immunity

Franconia Saal (Plenary Hall)

Gordon Brown

Plenary Speaker