Dr. Deepanjalee Dutta (Bremen, DE), Prof. Dr. Kurosch Rezwan (Bremen, DE), Prof. Dr. Dorothea Brüggemann (Bremen, DE), PD Dr. Michael Maas (Bremen, DE)
Abstract text (incl. figure legends and references)
Introduction: Ceramic textiles are used in high-temperature applications1 and may be suitable as wound dressing like previously reported anodic aluminium oxide (AAO).2
Objective: Here, we investigate tricot knit alumina ceramic textiles (Zircar Ceramics Inc., USA) as a flexible wound dressing that may shield the wound surface from external bacterial infection and capture bacteria already present in the wound.
Materials and Methods: E. coli and B. subtilis were incubated with alumina textiles and commercial dressings non-woven mesh (Cutimed® Sorbact®), a woven gauze (LEINA-WERKE) and a non-woven gauze (LEINA-WERKE) on agar plates to explore bacteria permeation (Fig. 1A) and attachment (Fig. 1B). After textile removal from the agar, visual analysis of agar plates and optical density measurements (595 nm) of the collected bacteria from the agar surface were performed. In addition, artificial wound bed tests with preformed biofilms were conducted (Fig 1C).
Results: After incubation with alumina textiles, negligible bacteria permeation was observed in the set up Fig.1A and most bacteria were captured from agar surface by textiles using set up in Fig 1B. SEM studies showed both types of bacteria attached to alumina textiles.They outperformed commercial dressings in capturing bacteria from agar surfaces and also in preventing bacteria permeation into agar surface.The results of the artificial wound bed tests show that the alumina textiles retained their bacteria capturing ability in this complex biological environment.
Conclusion: Due to their flexible and bioinert nature, alumina textiles show great potential as bacteria-capturing wound dressings which can be extended to different bacteria strains in the future.
Figure 1: (A, B) Design of the bacterial interaction study; (C) artificial wound bed tests with bacteria and alumina textiles
References
[1] D. B Marshall et al; Annu. Rev. Mater. Res.,2008.[2] D.Dutta et al; ACS Appl. Bio Materials,2021.