Sadaf Khalatbarizamanpoor (Jena, DE), Dr. Chuan Yin (Jena, DE), Dr. Lorena Tuchscherr (Jena, DE), Prof. Dr. Klaus D. Jandt (Jena, DE), Prof. Dr. Bettina Löffler (Jena, DE)
Abstract text (incl. figure legends and references)
Introduction:
In our aging society, implants are crucial in improving the quality of life, especially for older individuals. However, implant-associated infections are a significant complication of medical procedures and can lead to high healthcare costs and morbidity. Bacterial adherence to implant surfaces is the initial step in developing these infections. Different physical and chemical methods are employed to enhance the surface properties of medical implants, aiming to promote bio-integration and prevent bacterial adhesion.
Objectives:
Our objective in this study is to investigate the effect of oscillation on bacterial adherence and osteoblast growth on titanium discs with different roughness in the presence and absence of oscillation. We aim to investigate the potential of this mechanical stimulus for developing switchable antimicrobial materials.
Materials and Methods:
In this study, we used titanium discs with varying nano roughness levels as the implant surface. SaOs cells are seeded onto these discs, and two types of bacteria, namely S. aureus and S. epidermidis, are incubated with the discs. To assess the impact of oscillation, both systems are subjected to oscillation conditions, as well as a control without oscillation. The oscillation is induced along the x-axis using an oscillation-stimulating machine. The viability of the cells and the adherence of bacteria were evaluated using various assays.
We expect that oscillation reduces bacterial adherence to titanium and promotes osteoblast growth.