Dr. Kristina auf dem Brinke (Göttingen / DE), Dr. Fabian Kück (Göttingen / DE), Dr. Ala Jamous (Göttingen / DE), Dr. Andreas Leha (Göttingen / DE), Dr. Marielle Ernst (Göttingen / DE), PD Dr. med. Ilko Maier (Göttingen / DE)
Abstract-Text (inkl. Referenzen und Bildunterschriften)
Background and aims:
Postinterventional hypothermia is a frequent complication in patients with large vessel occlusion strokes (LVOS) after mechanical thrombectomy (MT). This inadvertent hypothermia might potentially have neuroprotective, but also adverse effects on patients" outcomes. We aimed to determine the rate of hypothermia in patients with LVOS receiving MT and its influence on functional outcome.
Methods:
We performed a monocentric, retrospective study using a prospectively derived databank including all LVOS patients receiving MT between 2011 and 2021. Predictive value of postinterventional body temperature and body temperature categories (hyperthermia (≥38°C), normothermia (36°C–37,9°C) and hypothermia (<36°C)) on functional outcome were analyzed using multivariable bayesian logistic regression models. Favorable outcome was defined as modified Rankin Scale (mRS) ≤3.
Results:
Of the 480 included LVOS-patients with MT (46.0% men, mean±SD age 73.0 ± 12.9 years), 5 (1.0%) were hyperthermic, 219 (45.6%) normothermic and 256 (53.3%) hypothermic. The rate of hypothermia was significantly higher in patients with unfavorable outcome after 90 days compared to in patients with favorable outcome (151 (58.8%) vs. 105 (47%); p=0.016). Lower postinterventional temperatures predicted unfavorable outcome at discharge (mRS>3: OR 0.71, 95%CI, 0.53-0.95, p=0.019 and NIHSS: exp(β) 0.93, 95%CI, 0.88-0.99, p=0.018) and after 90 days (mRS>3: OR 0.85, 95%CI, 0.68-1.08, p=0.178).
Conclusions:
More than half of the LVOS-patients in this cohort were hypothermic after MT. Hypothermia was an independent predictor of unfavorable functional outcome. Our findings warrant a prospective trial investigating active warming during MT.